Prof. Dr.
Thomas Dresbach   

Phone: +49 (0)551 397004
Fax.: +49 (0)551 397043

Profile Research Publications
Prof. Dr. Thomas Dresbach



Dresbach T. Active zone assembly. In: Presynaptic Terminals. Editor: Sumiko Mochida. Springer, Japan (in press).

Mendoza Schulz A, Jing Z, Sánchez Caro JM, Wetzel F, Dresbach T, Strenzke N, Wichmann C, Moser T (2014)
Bassoon-disruption slows vesicle replenishment and induces homeostatic plasticity at a CNS synapse. EMBO J 33:512-27.

Ahmed S, Wittenmayer N, Kremer T, Hoeber J, Kiran Akula A, Urlaub H, Islinger M, Kirsch J, Dean C, Dresbach T (2013)
Mover is a homomeric phospho-protein present on synaptic vesicles. PLoS One. 8:e63474

Murk K, Wittenmayer N, Michaelsen-Preusse K, Dresbach T, Schoenenberger CA, Korte M, Jockusch BM, Rothkegel M (2012)
Neuronal profilin isoforms are addressed by different signalling pathways. PLoS One. 7:e34167.

Schrof S, Staudt T, Rittweger E, Wittenmayer N, Dresbach T, Engelhardt J, Hell SW. (2011)
STED nanoscopy with mass-produced laser diodes. Opt Express. 19: 8066-72

Stan, A., Pielarski, K. N., Brigadski, T., Wittenmayer, N., Fedorchenko, O., Gohla., A., Lessmann, V., Dresbach, T., and Gottmann, K. (2010) Essential co-operation of N-Cadherin and Neuroligin-1 in the transsynaptic control of vesicle accumulation. Proc Natl Acad Sci U S A 107, 11116-21.

Wittenmayer N, Korber C, Liu H, Kremer T, Varoqueaux F, Chapman ER, Brose N, Kuner T, Dresbach T (2009). Postsynaptic Neuroligin1 regulates presynaptic maturation. Proc Natl Acad Sci U S A 106:13564-13569.

Tsuriel, S., Fischer, A., Wittenmayer, N., Dresbach, T., Garner, C.C., and Ziv, N.E. (2008) Exchange and Redistribution Dynamics of the Cytoskeleton of the Active Zone Molecule Bassoon. J. Neurosci. 14, 351-358.

Fairless, R., Masius H., Rohlmann A., Heupel, K., Ahmad, M., Reissner, C., Dresbach, T., and Missler, M. (2008) Polarized targeting of neurexins to synapses is regulated by their C-terminal sequences. J. Neurosci. 28, 12969-12981.

Kremer, T., Kempf, C., Wittenmayer, N., Nawrotzki, R., Kuner, T., Kirsch, J. and Dresbach, T. (2007) Mover is a novel vertebrate-specific presynaptic protein with differential distribution at subsets of CNS synapses. FEBS Lett. 581, 4727-4733.

Jose, M., Nair, D.K., Altrock, W.D., Dresbach. T., Gundefinger, E.D. and Zuschratter, W. (2007) Invesitgating interactions mediated by the presynaptic protein Bassoon in living cells by FRET-FLIM. Biophysical J., 1483-1496.

Tsuriel, S., Geva, R., Zamorano, P., Dresbach, T., Boeckers, T., Gundelfinger E.D., Garner, C.C. and Ziv, N.E. (2006) Local Sharing as a Predominant Determinant of Synaptic Matrix Molecular Dynamics. PLoS Biol. 4, e271.

Dresbach, T., Torres, V., Wittenmayer, N., Altrock, W.D., Zamorano, P., Zuschratter, W., Nawrotzki, R., Ziv, N.E., Garner, C.C. and Gundelfinger, E.D. (2006) Assembly of active zone precursor vesicles: obligatory trafficking of presynaptic cytomatrix proteins Bassoon and Piccolo via a trans-Golgi compartment. J. Biol. Chem. 281, 6038-6047.

Reim, K., Wegmeyer, H., Brandstätter, J.H., Xue, M., Rosenmund, C., Dresbach, T., Hofmann, K. and Brose, N. (2005) Structurally and functionally unique complexins at retinal ribbon synapses. J. Cell Biol. 169, 669-680.

Böckers, T.M., Liedke, T. Spilker, C., Dresbach, T., Bockmann, J., Kreutz, M.R. and Gundelfinger, E.D. (2005) C-terminal synaptic targeting elements for postynaptic density proteins ProSAP1/Shank2 and ProSAP2/Shank3. J. Neurochem. 92, 519-524.

Dresbach, T., Neeb, A., Meyer, G., Gundelfinger, E.D. and Brose, N. (2004) Synaptic targeting of Neuroligin is independent of neurexin and SAP90/PSD95 binding. Mol. Cell. Neurosci. 27, 227-235.

Bresler, T., Shapira, M., Böckers, T., Dresbach, T., Futter, M., Garner, C.C., Rosenblum, K., Gundelfinger, E.D. and Ziv, N.E. (2004) Postsynaptic density assembly is fundamentally different from presynaptic active zone assembly. J. Neurosci. 24, 1507-1520.

Dresbach, T., Hempelmann, A., Spilker, C., tom Dieck, S., Altrock, W.D., Zuschratter, W., Garner, C.C. and Gundelfinger, E.D. (2003) Functional regions of the presynaptic cytomatrix protein Bassoon: significance for synaptic targeting and cytomatrix anchoring. Mol. Cell. Neurosci. 23, 279-291.

Shapira, M, Zhai, R.G., Dresbach, T., Bresler, T., Torres, V.I., Gundelfinger, E.D., Ziv, N.E. and Garner, C.C. (2003) Unitary assembly of presynaptic active zones from Piccolo-Bassoon transport vesicles. Neuron 38, 237-252.

Altrock, W.D., tom Dieck, S., Sokolov, M., Meyer, A.C., Sigler, A., Brakebusch, C., Fassler, R., Richter, K., Böckers, T.M., Potschka, H., Brandt, C., Loscher, W., Grimberg, D., Dresbach, T., Hempelmann, A., Hassan, H., Balschun, D., Frey, J.U., Brandstatter, J.H., Garner, C.C., Rosenmund, C. and Gundelfinger, E.D. (2003) Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein Bassoon. Neuron 37, 787-800.

Spilker, C., Dresbach, T. and Braunewell, K.-H. (2002) Reversible translocation and activity-dependent localization of the calcium-myristoyl switch protein VILIP-1 to different membrane compartments in living hippocampal neurons. J. Neurosci. 22, 7331-7339.

Krämer, D., Dresbach, T. and Drenckhahn, D. (2001) Mrnp41(Rae1p) associates with microtubules in HeLa cells and in neurons. Eur. J. Cell Biol. 80, 733-740.

Sanmartí-Vila, L., tom Dieck, S., Richter, K., Altrock, W., Zhang, L., Volknandt, W., Zimmermann, H., Garner, C.C., Gundelfinger, E.D. and Dresbach, T. (2000) Membrane-association of presynaptic cytomatrix protein Bassoon. Biochem. Biophys. Res. Comm. 275, 43-46.

Bracher, A., Perrakis, A., Dresbach, T., Betz, H. and Weissenhorn, W. (2000) X-ray crystal structure of neuronal Sec1 from squid. Structure 8, 685-94.

Bracher, A., Dresbach, T., Betz, H. and Weissenhorn, W. (2000) Crystallization and preliminary X-ray analysis of squid neuronal Sec1. Acta Crytallographica D56, 501-503.

Dresbach, T., Burns, M.E., O'Connor, V., DeBello, W.M., Augustine, G.J. and Betz, H. (1998) A neuronal sec1 homolog regulates neurotransmitter release at the squid giant synapse. J. Neurosci. 18, 2923-2932.

Schweizer, F.E., Dresbach, T., DeBello, W.M., O'Connor, V., Augustine, G.J. and Betz, H. (1998) Regulation of neurotransmitter release kinetics by NSF. Science 279, 1203-1206.

O'Connor, V., Heuss, C., DeBello, W.M., Dresbach, T., Hunt, J.M., Charlton, M.P., Hodel, A., Burger, M.M., Augustine, G.J., Betz, H. and Schäfer, T. (1997) Disruption of syntaxin-mediated protein interactions blocks neurotransmitter secretion. Proc. Natl. Acad. Sci. U.S.A. 94, 12186-12191.

DeBello, W.M., O'Connor, V., Dresbach, T., Whiteheart, S.W., Wang, S.S., Schweizer, F.E., Betz, H., Rothman, J.E. and Augustine, G.J. (1995) SNAP-mediated protein-protein interactions essential for neurotransmitter release. Nature 373, 626-630.


Dresbach, T., Nawrotzki, R., Kremer, T., Schumacher, S., Quinones, D., Kluska, M., Kuhse, J., and Kirsch, J. (2008) Molecular architecture of glycinergic synapses. Histochem. Cell Biol. 130, 617-633.

Dean, C. and Dresbach, T. (2006) The Function of the Neurexin-Neuroligin Interaction in Synapse Formation: Implications for Brain Development and Autism. Trends Neurosci. 29, 21-29.

Dresbach, T., Altrock, W.D. and Gundelfinger, E.D. (2003). Neurotransmitterfreisetzung an chemischen Synapsen: Zusammenbau und molekulare Organisation der aktiven Zone. Neuroforum 3, 79-86.

Dresbach, T., Qualmann, B., Garner, C.C. and Gundelfinger, E.D. (2001). The presynaptic cytomatrix of brain synapses. Cell. Mol. Life Sci. 58, 94-116.

el Far, O., O'Connor, V., Dresbach, T., Pellegrini, L., DeBello, W., Augustine, G., Schafer, T., Charlton, M.P. und Betz, H. (1998). Protein interactions implicated in neurotransmitter release. J. Physiol. (Paris) 92, 129-133.

O'Connor, V., Pellegrini, L., Dresbach, T., Bommert, K., El Far, O., Betz, H., DeBello, W., Hunt, J.M., Schweizer, F., Augustine, G. und Charlton, M.P. (1996). Protein-protein interactions in synaptic vesicle exocytosis. Biochem. Soc. Transactions 24, 666-670.

Burns, M.E., Beushausen, S.A., Chin, G.J., Tang, D., DeBello, W.M., Dresbach, T., O'Connor, V., Schweizer, F.E., Wang, S.S. und Whiteheart, S.W. (1995). Proteins involved in synaptic vesicle docking and fusion. Cold Spring Harbor Symp. Quant. Biol. 60, 337-348.


Dresbach, T., Fejtová, A. and Gundelfinger, E.D. (2006). Assembly of presynaptic active zones. In : Molecular Mechanisms of Synaptogenesis (eds: El Husseini, A., and Dityatev, A.). Springer: Berlin, Heidelberg. 235-244.

Betz, H., O'Connor, V., Dresbach, T., Pellegrini, L., Bommert, K., DeBello, W., Hunt, J. M., Schweizer, F.E., Augustine, G., Charlton, M.P., Adams, R., Sato, K., Püschel, A.W., Sur, C. and Schloss, P. (1997). Proteins implicated in neurotransmitter release and reuptake. In: Neurotransmitter Release and Uptake (ed: S. Pögün). NATO ASI Series, Vol. H 100. Springer: Berlin, Heidelberg. pp 3-9.

Augustine, G.J., Betz, H., Bommert, K., Charlton, M.P., DeBello, W. M., Dresbach, T., Hunt, J.M., O'Connor, V., Schweizer, F.E., Wang, S.S.-H. and Whiteheart, S.W. (1996). Molecular mechanisms of neurotransmitter secretion: Functional studies at the squid giant synapse. In: Basic Neuroscience in Invertebrates (eds: H. Kike, Y. Kidokoro, K. Takahashi and T. Kanaseki). Japan Scientific Societies Press, Tokyo. pp 197-214.


Dresbach, T. (1996). "Cold Spring Harbor 1995: Imaging structure and function in the nervous system". Futura 2, 149-151.